Services

Flexible, high-quality next-generation sequencing to rapidly sequence whole genomes, whole exomes, targeted regions, microbiomes, and more

• CAP/CLIA validated
• Provides 30X coverage
• Suitable for rigorous clinical and medical research, compliant with clinical laboratory standards

• RUO/Exploratory
• Flexible coverage at 1X, 2X, & 4X
• Tailored to specific scientific inquiries & experimental needs
• Custom imputation services

• RUO/Exploratory
• Varying read lengths & depths
• Applicable for a variety of RNA types, including IVT RNA & other specialized RNA
• Small-scale targeted studies up to large-scale transcriptomic surveys
• Captures precise RNA dynamics across different conditions & treatments

• CAP/CLIA validated
• Provides 100x coverage
• Suitable for rigorous clinical & medical research, compliant with clinical laboratory standards

• RUO/Exploratory
• Single-cell RNA sequencing
• Parse Biosciences Certified Provider
• Custom project development for any project size
• Multiple sequencing platforms supported — Illumina & Complete Genomics
• Supports broad range of specimen types:
  • PBMCs
  • Cell lines
  • Fresh/frozen tissue
  • Pre-fixed samples
• Sample fixation services available
• End-to-end analysis with Parse Trailmaker app

• RUO/Exploratory
• Combined genome and methylome provides full genetic sequence including variants
• Single solution for multimodal data
• A true 6-base genome that distinguishes 5mC and 5hmC with all four canonical bases

• RUO/Exploratory
• High-performance enzyme-based alternative to bisulfite conversion for methylome analysis
• Superior detection of CpGs with fewer sequencing reads
• More uniform GC coverage

• RUO/Exploratory
• Sequences all genomic DNA present in a sample, including both host & microorganisms
• Provides insight into the taxonomic profile & abundances, functional predictions, gut-host relationships, drug discovery data, & more

• CAP/CLIA validated
• Flexible configurations available for read counts & sequencing depths
• Targets specific regions of the bacterial 16S rRNA gene to identify & understand the abundance of various microbial communities

• Regulatory level can be validated according to specific needs
• Deep coverage of specific genomic loci of interest
• Provides identification of common & rare variants that may be associated with a specific genetic condition or trait
• Uses capture-based probes to design a custom assay to suit any application

Customizable and accurate qPCR-based genotyping across a wide range of applications from small- to mid-size SNP panels

• RUO/Exploratory & CAP/CLIA validated options
• OpenArray® is an RT-PCR-based solution for multiple targets with a scalable number of samples
• Optimizes reagent utilization & increases sample throughput by utilizing a slide-size chip embedded with thousands of nanowells
• Customizable formats provide unmatched flexibility to select from thousands of predesigned or custom TaqMan assays pre-loaded onto OpenArray plates

• RUO/Exploratory & CAP/CLIA validated options
• Singleplex & multiplex assays 
• Customizable for SNPs of interest
• Rapid, cost-effective results for clinical diagnostics, genetic research, infectious studies, SNP analysis, & more

Viral Respiratory qPCR panels

• RUO/Exploratory
• Multiplex PCR technology, utilizing TaqMan probes to quickly survey many different pathogens in a single sample
• Pre-designed or custom options available
• Automated workflow for rapid, accurate results

Cutting-edge Illumina Infinium array technology to provide flexible options and valuable insight into clinical and research applications

• CAP/CLIA validated
• 654,027 fixed markers
• 24 or 48 samples per array
• High-throughput genotyping array, genome-wide genotyping array

• CAP/CLIA validated
• 1,825,277 fixed markers
• 8 samples per array
• Genome-wide genotyping array

• CAP/CLIA validated
• 1,933,117 total markers
• 8 samples per array
• Genome-wide genotyping array

• RUO/Exploratory
• ~930,000 markers
• 8 samples per array
• Methylation array, differentially methylated cytosines variant class

• RUO/Exploratory & CAP/CLIA validated options
• Customizable content supports up to 100k markers
• 24 samples per array
• Methylation array, differentially methylated cytosines

High-throughput and purpose-designed automation for high-quality sample extraction and preparation

Technology

• MagMAX™ DNA Multi-Sample Ultra 2.0 Kit
• ZymoBIOMICS MagBead DNA Kit
• MagMAX™ Viral / Pathogen Nucleic Acid Isolation Kit
• ZymoBIOMICS EZ-96 DNA Methylation-Lightning MagPrep Kit (Bisulfite Conversion)
• KOH Lysis

Platform

• Thermo Scientific™ KingFisher Flex
• Hamilton Microlab® STAR™
• BioSpec Mini-Beadbeater

Accurate and quick measurement of DNA/RNA concentration to ensure high-quality and dependable results

Technology

• TapeStation high sensitivity and broad range
• Qubit™ dsDNA/ssDNA/RNA
• KAPA qPCR library quantification
• Hemocytometer
• Cell Counter
• UV-Spec

Platform

• Agilent TapeStation 4200
• Invitrogen™ Qubit™ Flex & 3.0
• Applied Biosystems™ QuantStudio™ 5
• Invitrogen™ Countess™ II
• SpectraMax® M2

A comprehensive suite of automated, high-throughput library preparation and target enrichment kits for DNA, RNA, and epigenetic studies

Technology

• Illumina DNA Prep PCR-Free Kit
• Illumina DNA Prep Kit
• Illumina DNA Prep with Enrichment Kit
• Illumina Stranded Total RNA Prep Kit
• Watchmaker DNA Library Prep Kit
• Watchmaker RNA Library Prep Kit
• Zymo Quick-16S Plus NGS Library Prep Kit

Platform

• Hamilton Microlab® STAR™
• Manual

Kit development & logistics solutions tailored for small to mid-level projects

Technology

• Saliva & buccal swabs
• Whole blood
• Stool
• Vaginal

Platform

• Custom

Technology

• Temperature-controlled sample repository with secure access
• Efficient inventory management
• Stored commodities include USP-grade reagents, clinical study samples, bioanalytical samples, biomarkers, retain samples

Platform

• Ambient (15 – 20°C)
• Refrigerator (2 – 8°C)
• Freezer (-30°C)
• ULT (-80°C)
• LN2 (-196°C)

Clinical Enterprise is constantly developing new tests and designing custom workflows to meet your unique testing needs. We can support your most ambitious projects with a tailored project management and data delivery framework to meet your exact objectives.

The Clinical Enterprise team can bring success to any project with

• Highly-credential method development team
• Robust automated instrument platforms
• Hands-on, technical project design
• Deadline-driven project execution
• Qualified technical and commercial support 
• Customizable data delivery or integration