Services

Flexible, high-quality next-generation sequencing to rapidly sequence whole genomes, whole exomes, targeted regions, microbiomes, and more

Whole Genome Sequencing (WGS)

• LDT regulatory level
• Provides 30X coverage
• Suitable for rigorous clinical and medical research, compliant with clinical laboratory standards
• Explore Clinical Enterprise’s WGS

Low-Pass Whole Genome Sequencing (lp-WGS)

• RUO regulatory level
• Flexible coverage at 1X, 2X, & 4X
• Tailored to specific scientific inquiries & experimental needs
• Explore Clinical Enterprise’s WGS

Whole Transcriptome Sequencing (WTS)

• RUO regulatory level
• Varying read lengths & depths
• Applicable for a variety of RNA types, including IVT RNA & other specialized categories
• Small-scale targeted studies up to large-scale transcriptomic surveys
• Captures precise RNA dynamics across different conditions & treatments
• Explore Clinical Enterprise’s WTS

Whole Exome Sequencing (WES)

• LDT regulatory level
• Provides 100x coverage
• Suitable for rigorous clinical & medical research, compliant with clinical laboratory standards

Single-Cell RNA Sequencing (sc-RNA-Seq)

• RUO regulatory level
• Standard processing includes
  • 30-50k cells/sample
  • >20k reads/cell
  • ~1B reads/sample
• Supports broad range of specimen types:
  • PBMCs
  • Solid tumors
  • Developmental biology samples
• Cell fixation & varying range of reads available

Combined Genetic & Epigenetic Sequencing

• RUO regulatory level
• Combined genome and methylome provides full genetic sequence including variants
• Single solution for multimodal data
• A true 6-base genome that distinguishes 5mC and 5hmC with all four canonical bases

Enzymatic Methylation Sequencing (EM-Seq)

• RUO regulatory level
• High-performance enzyme-based alternative to bisulfite conversion for methylome analysis
• Superior detection of CpGs with fewer sequencing reads
• More uniform GC coverage

Shotgun Metagenomics (SGM)

• RUO regulatory level
• Sequences all genomic DNA present in a sample, including both host & microorganisms
• Provides insight into the taxonomic profile & abundances, functional predictions, gut-host relationships, drug discovery data, & more

16S Microbiome Profiling

• LDT regulatory level
• Flexible configurations available for read counts & sequencing depths
• Targets specific regions of the bacterial 16S rRNA gene to identify & understand the abundance of various microbial communities

Targeted Sequencing

• Regulatory level can be validated according to specific needs
• Deep coverage of specific genomic loci of interest
• Provides identification of common & rare variants that may be associated with a specific genetic condition or trait
• Uses capture-based probes to design a custom assay to suit any application

Customizable and accurate qPCR-based genotyping across a wide range of applications from small- to mid-size SNP panels

OpenArray 

• RUO & LDT regulatory levels
• OpenArray™ is an RT-PCR-based solution for multiple targets with a scalable number of samples
• Optimizes reagent utilization & increases sample throughput by utilizing a slide-size chip embedded with thousands of nanowells

qPCR

• RUO & LDT regulatory levels
• Singleplex & multiplex assays 
• Customizable for SNPs of interest
• Rapid, cost-effective results for clinical diagnostics, genetic research, infectious studies, SNP analysis, & more

Viral Respiratory qPCR panels

• RUO regulatory level
• Multiplex PCR technology, utilizing TaqMan probes to quickly survey many different pathogens in a single sample
• Pre-designed or custom options available
• Automated workflow for rapid, accurate results

Cutting-edge Illumina Infinium array technology to provide flexible options and valuable insight into clinical and research applications

Infinium Global Screening Array

• LDT regulatory level
• 654,027 fixed markers
• 24 or 48 samples per array
• High-throughput genotyping array, genome-wide genotyping array

Infinium Global Diversity Array

• LDT regulatory level
• 1,825,277 fixed markers
• 8 samples per array
• Genome-wide genotyping array

Infinium Global Diversity Array with Enhanced PGx

• LDT regulatory level
• 1,933,117 total markers
• 8 samples per array
• Genome-wide genotyping array

Infinium MethylationEPIC

• RUO regulatory level
• ~930,000 markers
• 8 samples per array
• Methylation array, differentially methylated cytosines variant class

Custom Methylation Array

• RUO & LDT regulatory levels
• SNP selection according to your needs
• Design of unique iSelect Custom BeadChips with Illumina
• Methylation array

High-throughput and purpose-designed automation for high-quality sample extraction and preparation

Technology

• Magmax DNA Multi-Sample Ultra 2.0
• ZymoBIOMICS MagBead DNA kit
• MagMaxViral / Pathogen Nucleic Acid Isolation Kit
• EZ-96 DNA Methylation-Lightning MagPrep (Bisulfite Conversion)
• KOH Lysis

Platform

• KingFisher
• Hamilton STAR
• BioSpecMini-Beadbeater

Accurate and quick measurement of DNA/RNA concentration to ensure high-quality and dependable results

Technology

• TapeStation high sensitivity and broad range
• Quibit dsDNA/ssDNA/RNA
• KAPA qPCR library quantification
• Hemocytometer
• Cell Counter
• UV-Spec

Platform

• TapeStation 4200
• Qubit Flex & 3.0
• ThermoFisher QuantStudio 5
• Countess II
• SpectraMax M2

A comprehensive suite of automated, high-throughput library preparation and target enrichment kits for DNA, RNA, and epigenetic studies

Technology

• Illumina DNA Prep PCR-Free (WGS)
• Watchmaker Genomics DNA (WGS)
• Illumina Stranded Total RNA (WTS)
• Watchmaker Genomics RNA (WTS)
• Illumina DNA Prep (SMG & Custom Projects)
• Illumina DNA Prep w/ Enrichment (WES)
• Zymo 16SV4 Quick Prep

Platform

• Hamilton STAR
• Manual

Kit development & logistics solutions tailored for small to mid-level projects

Technology

• Saliva & buccal swabs
• Whole blood
• Stool
• Vaginal

Platform

• Custom

Technology

• Temperature-controlled sample repository with secure access
• Efficient inventory management
• Stored commodities include USP-grade reagents, clinical study samples, bioanalytical samples, biomarkers, retain samples

Platform

• Ambient (15 – 20°C)
• Refrigerator (2 – 8°C)
• Freezer (-30°C)
• ULT (-80°C)
• LN2 (-196°C)

Clinical Enterprise is constantly developing new tests and designing custom workflows to meet your unique testing needs.

We can support your most ambitious projects with a tailored project management and data delivery framework to meet your exact objectives. 

Our development and project management teams can bring success to any project with hands-on technical project design, deadline-driven project execution, customizable data delivery or integration, and qualified technical support for our clients.